cv
general information
name | Kathleen T Quach |
summary | A behavioral neuroscientist with ten years of independent research experience, specializing in the application of ethological, neuroeconomic, and other behavioral frameworks to analyze decision-making processes of predator-prey interactions. |
education
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2019 PhD
Neurosciences, Specialization in Computational Neuroscience
University of California, San Diego
La Jolla, California, United States - GPA: 3.734 / 4.000
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2010 BS
Neuroscience
University of California, Los Angeles
Los Angeles, California, United States - GPA: 3.618 / 4.000
research experience
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09.2019 - 04.2024 Postdoctoral Fellow
PI: Sreekanth Chalasani
Molecular Neurobiology
Salk Institute for Biological Studies
La Jolla, California, United States - Led projects investigating the decision-making and molecular regulation of defensive behaviors by Caenorhabditis elegans nematodes in response to Pristionchus pacificus predators.
- Integrated concepts from predatory imminence theory and prey refuge theory to build a behavioral framework that can be used to predict, elicit, and interpret Caenorhabditis elegans defensive behaviors in response to changes in various dimensions of perceived predation risk.
- Conducted behavioral experiments on genetic mutants and transgenic strains to identify changes in interdependence between signaling partners across stages of defensive behaviors.
- Supervised a research assistant.
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07.2012 - 09.2019 Graduate Student
PI: Sreekanth Chalasani
Molecular Neurobiology
Salk Institute for Biological Studies
La Jolla, California, United States - Led projects investigating the decision-making and molecular regulation of foraging decisions by Pristionchus pacificus predatory nematodes in response to predator-prey competition with Caenorhabditis elegans prey nematodes.
- Integrated concepts from foraging theory, neuroeconomic theory, and intraguild predation theory to build a behavioral framework that can be used to predict, elicit, and distinguish between predatory and territorial motivations for attacking Caenorhabditis elegans.
- Conducted a screen of pharmacologically active compounds to identify signaling mechanisms underlying the switch between predatory and territorial motivation, using the behavioral framework to directly target decision-making processes rather than motor or sensory processes.
- Supervised three research assistants.
- Other projects
- Co-led a project investigating whole-brain activity of Caenorhabditis elegans nematodes to understand how state-dependent network interactions gate sensory input at the motor and command neuron level.
- Supported a project investigating neural regulation of hypoxia responses in Danio rerio zebrafish.
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02.2009 - 06.2010 Undergraduate Research Assistant
PI: Mirella Dapretto
Psychiatry and Biobehavioral Sciences
University of California, Los Angeles
Los Angeles, California, United States - Conducted independent research investigating abnormal effective connectivity during emotional face processing in children with autism spectrum disorder.
- Applied dynamic causal modeling to fMRI time series data to estimate directionality and strength of coupling between brain regions during viewing of emotional faces.
- Developed methods for automating data entry of survey inputs from test subjects.
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01.2010 - 06.2010 Undergraduate Research Assistant
PI: Jack Van Horn
Neurology
University of California, Los Angeles
Los Angeles, California, United States - Designed graphical user interface elements for Invizian neuroinformatics software.
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03.2009 - 06.2010 Undergraduate Research Assistant
PI: Susan Bookheimer
Psychiatry and Biobehavioral Sciences
University of California, Los Angeles
Los Angeles, California, United States - Scored eye gaze behavior of 36-month old infants with autism spectrum disorder and their siblings during social interaction with caregivers and strangers.
- Drew regions of interests to quantify how much time is spent looking at facial, body, and background features.
- Developed code for automated parsing of Tobii software output.
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06.2007 - 09.2009 Undergraduate Research and Therapist Assistant
PI: Jeffrey Wood
Child and Adolescent Psychiatry
Semel Institute, University of California, Los Angeles
Los Angeles, California, United States - Assisted in cognitive behavioral therapy for treatment of anxiety in children with autism spectrum disorder.
- Performed data entry of therapy intake assessments and patient questionnaires for analysis in SPSS.
industry experience
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12.2011 - 06.2012 Implementation Specialist
Starbucks Coffee Company
Seattle, Washington, United States - Analyzed data and implemented strategies for optimizing the function of retail networks and public Wi-Fi in over 10,000 Starbucks stores across North America.
teaching and mentoring experience
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11.2023 - 12.2023 Application Reviewer
Summer Undergraduate Research Fellowship (SURF)
Salk Institute for Biological Studies
La Jolla, California, United States - Reviewed anonymized applications from under-resourced undergraduate applicants, using a rubric that assessed need and career goals.
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06.2023 Developer & Presenter
Workshop: Thinking like a Scientist
Summer Undergraduate Research Fellowship (SURF)
Salk Institute for Biological Studies
La Jolla, California, United States - Developed and presented a workshop introducing undergraduate interns to the values and philosophy guiding scientific research, and the principles of fostering a scientific personality resilient to failures and biases.
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05.2023 - 08.2023 Mentor
Summer Undergraduate Research Fellowship (SURF)
Salk Institute for Biological Studies
La Jolla, California, United States - Intensively mentored undergraduates from under-resourced institutions to perform independent research in a 10-week program.
- Mentee investigated the genetic expression of oxidative stress genes in prey exposed to various predator conditions.
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09.2022 - 11.2022 Tutor
Chemistry
Monarch School
San Diego, California, United States - Tutored chemistry to students impacted by homelessness to compensate for shortage of science teachers.
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05.2022 - 08.2022 Mentor
Summer Undergraduate Research Fellowship (SURF)
Salk Institute for Biological Studies
La Jolla, California, United States - Intensively mentored undergraduates from under-resourced institutions to perform independent research in a 10-week program.
- Mentee investigated the role of a serotonin receptor in the resilience of prey exposed to predator early or late in life.
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09.2020 - 02.2021 Mentor
Biology Undergraduate and Master's Mentorship Program (BUUMP)
University of California, San Diego
La Jolla, California, United States - Mentored biology undergraduate students from underrepresented minorities.
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03.2016 - 06.2016 Course Developer & Instructor
Course: Fundamentals of Statistics and Computation for Neuroscientists
University of California, San Diego
La Jolla, California, United States - Developed and taught a graduate-level introductory course designed to provide literacy and entry-level competency in computational techniques.
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09.2015 - 12.2015 Teaching Assistant
Course: Introduction to Methods in Computational Neuroscience
University of California, San Diego
La Jolla, California, United States - Assisted in teaching a graduate-level course on mathematical foundations and applications of computational neuroscience methods.
publications
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Interdependence between SEB-3 and NLP-49 peptides shifts across predator-induced defensive behavioral modes in Caenorhabditis elegans
Kathleen T Quach, Gillian A Hughes, Sreekanth H Chalasani
bioRxiv (under review at eLife), 2024
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Flexible reprogramming of Pristionchus pacificus motivation for attacking Caenorhabditis elegans in predator-prey competition
Kathleen T Quach, Sreekanth H Chalasani
Current Biology, 2022
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State-dependent network interactions differentially gate sensory input at the motor and command neuron level in Caenorhabditis elegans
Zachary T Cecere*, Kathleen T Quach*, Eviatar Yemini, Javier J How, Tatyana O Sharpee, Sreekanth H Chalasani (*co-first authors)
bioRxiv, 2021
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Intraguild predation between Pristionchus pacificus and Caenorhabditis elegans: a complex interaction with the potential for aggressive behaviour
Kathleen T Quach, Sreekanth H Chalasani
Journal of Neurogenetics, 2020
awards
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12.2022 - 11.2024 Maximillian E. and Marion O. Hoffman Foundation Award
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06.2020 - 06.2022 Paul F. Glenn Center for Biology of Aging Research Fellow
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07.2018 - 07.2019 Salk Women and Science Award
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03.2018 - 03.2019 Mary K. Chapman Foundation Award
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03.2018 Jesse and Caryl Philips Foundation Award
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05.2016 UCSD Neurosciences Graduate Teaching Award
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10.2015 Jesse and Caryl Philips Foundation Award
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09.2014 - 08.2017 National Science Foundation Graduate Research Fellow
skills
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laboratory
- model organisms
- Caenorhabditis elegans (nematode)
- Pristionchus pacificus (nematode)
- Danio rerio (zebrafish)
- human
- behavior
- predator-prey interaction
- foraging
- chemotaxis
- adaptation
- exploration
- egg-laying
- microscopy
- brightfield/DIC/fluorescence
- light/confocal
- laser microsurgery
- calcium imaging
- expansion
- staining
- immunocytochemistry
- DiI/DiO (neuronal tracer)
- Oil Red O (fat stain)
- pharmacology
- drug screens using LOPAC 1280
- neurotransmitters and associated agonists/antagonists
- paralytics
- bacteria
- culturing/incubation
- streaking/spreading/plating
- colony counting
- spectrophotometry
- transformation
- antibiotic selection
- microfluidics
- device fabrication
- device operation
- automated control of laminar flows
- molecular biology
- cloning
- DNA/RNA purification
- PCR
- primer design
- gel electrophoresis
- DNA/RNAseq
- DNA/RNA quantity/quality assessment
- model organisms
-
computational methods
- theories & frameworks
- foraging theory
- expected utility theory
- intraguild predation theory
- predatory imminence theory
- prey refuge theory
- information theory
- statistics
- tests for nominal variables
- parametric/non-parametric tests for one/multiple measurement variable(s)
- ANCOVA
- linear/nonlinear correlation
- linear/logistic regression models
- linear mixed-effects models
- bootstrapping
- data transformation
- distributional analysis
- power analysis
- machine-learning
- image processing
- image segmentation
- image deconvolution
- morphological processing
- fluorescence intensity quantification
- color deconvolution
- neural dynamics
- time series analysis
- dimensionality reduction
- network analysis
- network modeling
- theories & frameworks
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software, platforms, & languages
- scientific computing
- R
- MATLAB
- Python
- image acquisition and processing
- ImageJ
- Zen
- Streampix
- Metamorph
- bioinformatics
- APE
- Geneious
- BLAST
- Primer-BLAST
- Galaxy
- UCSC Genome Browser
- IGV
- OS
- Windows
- Linux (Ubuntu)
- Adobe
- Acrobat
- Illustrator
- Photoshop
- InDesign
- Microsoft Office
- Word
- Excel
- OneNote
- Google
- Drive
- Docs
- Sheets
- Slides
- Forms
- collaboration
- Zoom
- Slack
- electronic lab notebook
- Benchling
- inventory management
- Quartzy
- command line
- BASH
- Powershell
- web
- HTML
- Markdown
- CSS
- typesetting
- LaTeX
- Overleaf
- TeXmaker
- version control
- Git
- Github
- container
- Docker
- IDE
- Visual Studio
- data serialization formats
- JSON
- YAML
- diagramming
- PlantUML
- scientific computing